Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | LTA4H | P09960 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751133 | 0.85 | CHIT1 (0.51) | DRD1LTA4HSLC6A2SLC6A4LMNA | |
| SCHEMBL1752054 | 0.85 | KDM4E (0.46) | DRD1LTA4HSLC6A2SLC6A4LMNA | |
| SCHEMBL1751454 | 0.85 | LTA4H (0.50) | DRD1LTA4HSLC6A2SLC6A4LMNA | |
| SCHEMBL1752051 | 0.85 | KCNA5 (0.48) | DRD1LMNAHTTDRD2SMN1; SMN2 | |
| SCHEMBL12050103 | 0.85 | DRD2 (0.50) | DRD1LTA4HSLC6A2SLC6A4LMNA | |
| SCHEMBL1752104 | 0.83 | KDM4E (0.48) | LMNAHTTMAPTHPGDTSHR | |
| SCHEMBL1752484 | 0.83 | LTA4H (0.55) | DRD1LTA4HLMNASMN1; SMN2MAPT | |
| SCHEMBL1752005 | 0.83 | HRH3 (0.54) | DRD2RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL1752577 | 0.82 | KDM4E (0.56) | MEN1KMT2AKDM4E | |
| SCHEMBL1752622 | 0.81 | TBXAS1 (0.49) | LTA4HDRD2TSHRALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | claimed |
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | LI SONG | 2011-03-10 | — | — | US | claimed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | claimed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | claimed |
| US-8410105-B2 | Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-04-02 | — | — | US | disclosed |
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | disclosed |
| US-8076339-B2 | Pyridazine compound; also useful against rhinovirus | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing (CN) | 2011-12-13 | — | — | US | disclosed |
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | LI SONG | 2011-03-10 | — | — | US | disclosed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | disclosed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | RNASEH1, PIR, HAVCR2 | DRD1 4298/4885LTA4H 3580/4885SLC6A2 2986/4885 |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | RNASEH1, PIR, HAVCR2 | DRD1 4298/4885LTA4H 3580/4885SLC6A2 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.