Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | F9 | P00740 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551145 | 0.84 | HTT (0.51) | HTTF9SMN1; SMN2GAATSHR | |
| SCHEMBL16176491 | 0.84 | HTT (0.51) | HTTF9SMN1; SMN2GAATSHR | |
| SCHEMBL16176294 | 0.83 | PRKAG1 (0.68) | HTTF9SMN1; SMN2GAATP53 | |
| SCHEMBL10310242 | 0.83 | F10 (0.47) | HTTF9SMN1; SMN2GAATP53 | |
| SCHEMBL19378074 | 0.82 | BCHE (0.49) | HTTF9SMN1; SMN2TP53LMNA | |
| SCHEMBL11217654 | 0.82 | PRKAG1 (0.69) | PRKAG1PRKAA2PRKAA1PRKAB1MAPT | |
| SCHEMBL16176662 | 0.81 | THRB (0.60) | HTTF9SMN1; SMN2TP53LMNA | |
| SCHEMBL12402240 | 0.80 | TDP1 (0.45) | HTTF9SMN1; SMN2GAATP53 | |
| SCHEMBL10454789 | 0.80 | HTT (0.76) | HTTSMN1; SMN2GAATSHRRECQL | |
| SCHEMBL16176523 | 0.79 | ALDH1A1 (0.61) | HTTSMN1; SMN2TP53LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016029146-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON (US) | 2016-02-25 | — | — | WO | claimed |