Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | F9 | P00740 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17513340 | 0.84 | HTT (0.51) | HTTSMN1; SMN2GAATSHRRECQL | |
| SCHEMBL16176491 | 0.84 | HTT (0.51) | HTTSMN1; SMN2GAATSHRRECQL | |
| SCHEMBL16176662 | 0.81 | THRB (0.60) | HTTSMN1; SMN2POLBLMNATHRB | |
| SCHEMBL10454789 | 0.80 | HTT (0.76) | HTTSMN1; SMN2GAATSHRRECQL | |
| SCHEMBL16176523 | 0.79 | ALDH1A1 (0.61) | HTTSMN1; SMN2POLBLMNATHRB | |
| SCHEMBL9513404 | 0.79 | TSHR (0.47) | SMN1; SMN2TSHRLMNAIDO1MAPT | |
| SCHEMBL13406268 | 0.78 | TP53 (0.61) | SMN1; SMN2CTSSLMNATHRBMAPT | |
| SCHEMBL16176294 | 0.78 | PRKAG1 (0.68) | HTTSMN1; SMN2GAATSHRRECQL | |
| SCHEMBL13406272 | 0.78 | CTSS (0.59) | CTSSLMNATHRBMAPTALDH1A1 | |
| SCHEMBL13406273 | 0.77 | CTSS (0.58) | SMN1; SMN2CTSSLMNATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |