Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592328 | 0.88 | IRAK4 (0.37) | TYMPLMNAHTTIRAK4 | |
| SCHEMBL2631006 | 0.78 | CYP1A2 (0.32) | FFAR4CYP1A2CYP2D6LMNAHTT | |
| SCHEMBL30911787 | 0.76 | TYMP (0.40) | TYMPFFAR4CYP1A2CYP2D6PGK1 | |
| SCHEMBL1752221 | 0.76 | DRD2 (0.50) | MAPT | |
| SCHEMBL1751834 | 0.75 | CHEK2 (0.39) | MAPT | |
| SCHEMBL5884802 | 0.75 | LMNA (0.58) | CYP1A2MAPTLMNAHTT | |
| SCHEMBL1751677 | 0.73 | CHEK2 (0.41) | — | |
| SCHEMBL1752031 | 0.73 | DRD2 (0.40) | CYP2D6MAPTACHELMNA | |
| SCHEMBL1751628 | 0.73 | SIGMAR1 (0.41) | — | |
| SCHEMBL1751870 | 0.73 | MAPT (0.42) | MAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410105-B2 | Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-04-02 | — | — | US | disclosed |
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | disclosed |
| US-8076339-B2 | Pyridazine compound; also useful against rhinovirus | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing (CN) | 2011-12-13 | — | — | US | disclosed |
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | LI SONG | 2011-03-10 | — | — | US | disclosed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | disclosed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | RNASEH1, PIR, HAVCR2 | TYMP 210/4885FFAR4 4320/4885CYP1A2 1277/4885 |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | RNASEH1, PIR, HAVCR2 | TYMP 210/4885FFAR4 4320/4885CYP1A2 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.