Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17040984 | 0.85 | TSHR (0.47) | HPGDTSHRALDH1A1RAB9AMAPK1 | |
| SCHEMBL28307516 | 0.83 | ALDH1A1 (0.41) | HPGDTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL13881560 | 0.79 | ALDH1A1 (0.62) | HPGDALDH1A1RAB9ASRC | |
| SCHEMBL3794601 | 0.79 | L3MBTL1 (0.53) | HPGDTSHRALDH1A1RAB9AMAPK1 | |
| SCHEMBL5477791 | 0.78 | ALDH1A1 (0.68) | HPGDTSHRALDH1A1RAB9AMAPK1 | |
| SCHEMBL2851634 | 0.76 | ALDH1A1 (0.48) | HPGDALDH1A1 | |
| SCHEMBL8347835 | 0.76 | KDM4E (0.59) | HPGDALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL3042839 | 0.75 | PTGDR2 (0.44) | HPGDALDH1A1RAB9AL3MBTL1KMT2A | |
| SCHEMBL3787403 | 0.75 | MAPT (0.58) | HPGDTSHRALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL13938554 | 0.75 | PTGES (0.56) | HPGDALDH1A1RAB9AMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9265773-B2 | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases | MERCK SHARP & DOHME CORP. (US) | 2016-02-23 | — | — | US | disclosed |