Sugi Predict

Sugi Predict / Compounds / SCHEMBL1752667

SCHEMBL1752667

SCHEMBL1752667

C=CCN(CC=C)c1ccc2c(C)cc(=O)oc2c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 11/20 0.70
▸ HPGD P15428 9/20 0.70
▸ IGLV6-57 P01721 6/20 0.70
▸ GLA P06280 6/20 0.70
▸ HSD17B10 Q99714 6/20 0.70
▸ CASP1 P29466 3/20 0.70
▸ CASP7 P55210 3/20 0.70
▸ CYP3A4 P08684 2/20 0.70
▸ L3MBTL1 Q9Y468 2/20 0.70
▸ MAPK1 P28482 1/20 0.70
▸ ATM Q13315 1/20 0.70
▸ HIF1A Q16665 1/20 0.70
▸ KDM4E B2RXH2 7/20 0.50
▸ GAA P10253 5/20 0.50
▸ CA9 Q16790 4/20 0.50
▸ MAPT P10636 3/20 0.50
▸ KMT2A Q03164 3/20 0.50
▸ CA12 O43570 3/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ CYP1A2 P05177 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24590085 0.89 IGLV6-57 (0.80) ALDH1A1HPGDIGLV6-57GLAHSD17B10
SCHEMBL24590111 0.88 IGLV6-57 (0.71) ALDH1A1HPGDIGLV6-57GLAHSD17B10
SCHEMBL16296942 0.84 ALDH1A1 (0.49) ALDH1A1HPGDIGLV6-57GLAHSD17B10
SCHEMBL3950391 0.83 ALDH1A1 (0.68) ALDH1A1HPGDIGLV6-57GLAHSD17B10
Allylamine SCHEMBL28406883 0.83 ALDH1A1 (0.78) ALDH1A1HPGDIGLV6-57GLAHSD17B10
SCHEMBL384286 0.82 ALDH1A1 (1.00) ALDH1A1HPGDIGLV6-57GLAHSD17B10
SCHEMBL29362472 0.82 ALDH1A1 (1.00) ALDH1A1HPGDIGLV6-57GLAHSD17B10
SCHEMBL67108 0.82 ALDH1A1 (1.00) ALDH1A1HPGDIGLV6-57GLAHSD17B10
SCHEMBL8813329 0.82 IGLV6-57 (0.47) ALDH1A1HPGDIGLV6-57GLAHSD17B10
SCHEMBL16985193 0.81 ALDH1A1 (0.43) ALDH1A1HPGDIGLV6-57GLAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024090571-A1 DIAGNOSIS OF IMMUNE-MEDIATED INFLAMMATORY DISEASES USING MMP12 AS INDICATOR, AND MEDICINE FOR TREATING IMMUNE-MEDIATED INFLAMMATORY DISEASES VIA MMP12 INHIBITION 慶應義塾 2024-05-02 — — WO disclosed
US-11945806-B2 Stabilization of amyloidogenic immunoglobulin light chains THE SCRIPPS RESEARCH INSTITUTE 2024-04-02 — — US disclosed
US-20220204485-A1 STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS THE SCRIPPS RESEARCH INSTITUTE 2022-06-30 — — US disclosed
US-20220204485-A1 STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS THE SCRIPPS RESEARCH INSTITUTE 2022-06-30 — — US disclosed
EP-3946604-A1 BENZOPYRANE AND IMIDAZOLE DERIVATIVES USEFUL FOR THE STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS The Scripps Research Institute (US) 2022-02-09 — — EP disclosed
WO-2020205683-A1 BENZOPYRANE AND IMIDAZOLE DERIVATIVES USEFUL FOR THE STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS THE SCRIPPS RESEARCH INSTITUTE (US) 2020-10-08 — — WO disclosed
US-7968735-B2 Light-emitting biomarker QUIDD (FR) 2011-06-28 — — US disclosed
US-20090041669-A1 Light-Emitting Biomarker QUIDD (FR) 2009-02-12 — — US disclosed
EP-1883635-A2 LIGHT-EMITTING BIOMARKER Quidd (FR) 2008-02-06 — — EP disclosed
WO-2006129036-A2 LIGHT-EMITTING BIOMARKER QUIDD (FR) 2006-12-07 — — WO disclosed
US-4931223-A MIXTURE RELEASING LIGHT OF DIFFERENT WAVELENGTHS BY ENZYME DECOMPOSITION TROPIX, INC. (US) 1990-06-05 — — US disclosed
EP-0368946-A1 1,2-DIOXETANES. QUEST SYSTEMS INC (US) 1990-05-23 — — EP disclosed
EP-0368946-A4 1,2-DIOXETANES. QUEST SYSTEMS INC (US) 1990-05-14 — — EP disclosed
WO-1990000168-A1 IMPROVED METHODS OF USING CHEMILUMINESCENT 1,2-DIOXETANES TROPIX, INC. (US) 1990-01-11 — — WO disclosed
WO-1990000164-A1 NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED TROPIX, INC. (US) 1990-01-11 — — WO disclosed
EP-0275260-A4 METHOD OF DETECTING A SUBSTANCE USING ENZYMATICALLY-INDUCED DECOMPOSITION OF DIOXETANES. QUEST SYSTEMS INC (US) 1990-01-08 — — EP disclosed
WO-1989006226-A1 SYNTHESIS OF 1,2-DIOXETANES AND INTERMEDIATES THEREFOR QUEST SYSTEMS, INC. (US) 1989-07-13 — — WO disclosed
EP-0275260-A1 METHOD OF DETECTING A SUBSTANCE USING ENZYMATICALLY-INDUCED DECOMPOSITION OF DIOXETANES. QUEST SYSTEMS INC (US) 1988-07-27 — — EP disclosed
WO-1988000695-A1 METHOD OF DETECTING A SUBSTANCE USING ENZYMATICALLY-INDUCED DECOMPOSITION OF DIOXETANES QUEST SYSTEMS, INC. (US) 1988-01-28 — — WO disclosed
US-4235597-A OPTICAL BRIGHTENERS CIBA-GEIGY CORPORATION (US) 1980-11-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220204485-A1 STABILIZATION OF AMYLOIDOGENIC IMMUNOGLOBULIN LIGHT CHAINS TTR, MAP1LC3B, SAAL1 ALDH1A1 2072/4885HPGD 3113/4885IGLV6-57 7/4885
US-20090041669-A1 Light-Emitting Biomarker ALDH1A2, CYP19A1, GUSB ALDH1A1 7/4885HPGD 85/4885IGLV6-57 3121/4885
US-11945806-B2 Stabilization of amyloidogenic immunoglobulin light chains TTR, MAP1LC3B, SAAL1 ALDH1A1 2072/4885HPGD 3113/4885IGLV6-57 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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