Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 13/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | STAT6 | P42226 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 1.00 |
| ▸ | CASP1 | P29466 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 1/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Parthenolide SCHEMBL29811034 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL6479221 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL20438846 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL8219 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL14418063 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL14339765 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL8220 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL13367522 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL21998728 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 | |
| Parthenolide SCHEMBL30383005 | 1.00 | PKM (1.00) | PKMALDH1A1LMNATP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9463170-B2 | Chemosensory receptor ligand-based therapies | ELCELYX THERAPEUTICS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-9463170-B2 | Chemosensory receptor ligand-based therapies | ELCELYX THERAPEUTICS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150265555-A1 | Chemosensory Receptor Ligand-Based Therapies | ANJI PHARMACEUTICALS INC. | 2015-09-24 | — | — | US | disclosed |
| US-20150265555-A1 | Chemosensory Receptor Ligand-Based Therapies | ANJI PHARMACEUTICALS INC. | 2015-09-24 | — | — | US | disclosed |
| US-8158372-B2 | Agonists of a bitter taste receptor and uses thereof | DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG POTSDAM-REHBRÜCKE (DE) | 2012-04-17 | — | — | US | disclosed |
| US-8158372-B2 | Agonists of a bitter taste receptor and uses thereof | DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG POTSDAM-REHBRÜCKE (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20100056621-A1 | AGONISTS OF A BITTER TASTE RECEPTOR AND USES THEREOF | DEUTSCHES INSTITUT FUR ERNAHRUNGSFORSCHUNG (DE) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150265555-A1 | Chemosensory Receptor Ligand-Based Therapies | TAS1R2, TAS2R1, GPR119 | PKM 2269/4885ALDH1A1 764/4885LMNA 3720/4885 |
| US-20100056621-A1 | AGONISTS OF A BITTER TASTE RECEPTOR AND USES THEREOF | TAS2R4, TAS2R30, TAS2R40 | PKM 3972/4885ALDH1A1 2399/4885LMNA 4825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.