Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753652 | 0.73 | LMNA (0.39) | HTTLMNAMEN1KMT2AATM | |
| SCHEMBL26232902 | 0.72 | CYP1A2 (0.45) | LMNAMEN1KMT2AATMRAB9A | |
| SCHEMBL12051523 | 0.70 | ALDH1A1 (0.45) | LMNAMEN1KMT2AAHRNPC1 | |
| SCHEMBL31591033 | 0.70 | ALDH1A1 (0.45) | LMNAMEN1KMT2AAHRNPC1 | |
| SCHEMBL197716 | 0.70 | ALDH1A1 (0.52) | LMNATHRBMEN1KMT2AATM | |
| SCHEMBL4188897 | 0.67 | DHFR (0.54) | KDR | |
| SCHEMBL25917597 | 0.66 | UHRF1 (0.41) | LMNAMEN1KMT2AATMPDE10A | |
| SCHEMBL16682364 | 0.66 | HASPIN (0.35) | HTTLMNAMEN1KMT2AAHR | |
| SCHEMBL8885415 | 0.66 | LMNA (0.50) | HTTLMNATHRBMEN1KMT2A | |
| SCHEMBL27409908 | 0.66 | CYP1A2 (0.49) | HTTLMNAAURKAKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158820-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-17 | — | — | US | disclosed |