Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SDHB | P21912 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753548 | 0.73 | HTT (0.47) | LMNAKMT2AMEN1ATMCCR6 | |
| SCHEMBL16192818 | 0.72 | TP53 (0.40) | LMNATP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2350715 | 0.72 | MAPT (0.42) | LMNATP53SDHBKMT2AMEN1 | |
| SCHEMBL2111568 | 0.71 | IDO1 (0.40) | LMNATP53ABL1KMT2AMEN1 | |
| SCHEMBL197716 | 0.69 | ALDH1A1 (0.52) | LMNATP53KMT2AMEN1ATM | |
| SCHEMBL26232902 | 0.67 | CYP1A2 (0.45) | LMNAKMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL24349461 | 0.66 | TP53 (0.32) | LMNATP53ALDH1A1NPC1MAPT | |
| SCHEMBL4188897 | 0.66 | DHFR (0.54) | — | |
| SCHEMBL10582722 | 0.65 | TP53 (0.41) | LMNATP53ABL1KMT2AMEN1 | |
| SCHEMBL7586541 | 0.65 | MAPT (0.55) | LMNATP53KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158820-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-17 | — | — | US | disclosed |