Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 3/20 | 0.51 |
| ▸ | KLK1 | P06870 | 3/20 | 0.51 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.51 |
| ▸ | PLK1 | P53350 | 8/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.50 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16088643 | 0.95 | ALOX15 (0.54) | ALOX15PLGKLK1KLK6PLK1 | |
| SCHEMBL16127959 | 0.85 | ALOX15 (0.54) | ALOX15MEN1KMT2A | |
| SCHEMBL16127932 | 0.85 | ALOX15 (0.43) | ALOX15MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL17531726 | 0.85 | PLK1 (0.59) | ALOX15PLGKLK1KLK6PLK1 | |
| SCHEMBL17122454 | 0.83 | ALDH1A1 (0.58) | PLGKLK1KLK6MEN1KMT2A | |
| SCHEMBL12614440 | 0.82 | ALDH1A1 (0.63) | ALOX15KMT2AALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL16088636 | 0.81 | F2 (0.43) | ALOX15PLGMEN1KMT2AALDH1A1 | |
| SCHEMBL16127829 | 0.81 | HTT (0.49) | ALOX15PLGMEN1KMT2A | |
| SCHEMBL16127941 | 0.80 | ALOX15 (0.43) | ALOX15MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL16127945 | 0.80 | ALOX15 (0.54) | ALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11045476-B2 | Compounds and methods for inducing chondrogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-06-29 | — | — | US | disclosed |
| US-20200188407-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE SCRIPPS RESEARCH INSTITUTE | 2020-06-18 | — | — | US | disclosed |
| US-9452170-B2 | Compounds and methods for inducing chondrogenesis | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-09-27 | — | — | US | disclosed |
| US-20160045514-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11045476-B2 | Compounds and methods for inducing chondrogenesis | COL2A1, BMP4, COL1A1 | ALOX15 675/4885PLG 1665/4885KLK1 4250/4885 |
| US-20160045514-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | COL2A1, BMP4, COL1A1 | ALOX15 675/4885PLG 1665/4885KLK1 4250/4885 |
| US-20200188407-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | COL2A1, BMP4, COL1A1 | ALOX15 675/4885PLG 1665/4885KLK1 4250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.