Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544495

SCHEMBL17544495

SCHEMBL17544495

Cc1cccc(-c2nc3cc(Br)cnc3o2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PBRM1 Q86U86 1/20 0.46
▸ GRM5 P41594 1/20 0.45
▸ RAB9A P51151 13/20 0.45
▸ NPC1 O15118 12/20 0.45
▸ SMN1; SMN2 Q16637 11/20 0.44
▸ MAPT P10636 6/20 0.44
▸ HPGD P15428 6/20 0.44
▸ TSHR P16473 3/20 0.44
▸ KDM4E B2RXH2 8/20 0.43
▸ ALDH1A1 P00352 5/20 0.43
▸ NFKB1 P19838 2/20 0.43
▸ NFKB2 Q00653 2/20 0.43
▸ RELA Q04206 2/20 0.43
▸ PTGES O14684 1/20 0.42
▸ HSD17B10 Q99714 4/20 0.41
▸ TP53 P04637 4/20 0.41
▸ CASP3 P42574 3/20 0.41
▸ SENP8 Q96LD8 3/20 0.41
▸ SENP7 Q9BQF6 3/20 0.41
▸ SENP6 Q9GZR1 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30402371 1.00 PBRM1 (0.46) PBRM1GRM5RAB9ANPC1SMN1; SMN2
SCHEMBL2245217 0.84 SMN1; SMN2 (0.52) RAB9ANPC1SMN1; SMN2MAPTHPGD
SCHEMBL17544208 0.83 RAB9A (0.52) PBRM1GRM5RAB9ANPC1SMN1; SMN2
SCHEMBL30402429 0.83 RAB9A (0.52) PBRM1GRM5RAB9ANPC1SMN1; SMN2
SCHEMBL17543948 0.79 ALDH1A1 (0.52) RAB9ANPC1SMN1; SMN2MAPTHPGD
SCHEMBL13822263 0.79 PBRM1 (0.47) PBRM1GRM5RAB9ANPC1SMN1; SMN2
SCHEMBL11645943 0.75 RAB9A (0.58) RAB9ANPC1SMN1; SMN2MAPTHPGD
SCHEMBL2592319 0.74 RAB9A (0.62) PBRM1RAB9ANPC1SMN1; SMN2MAPT
SCHEMBL30824964 0.73 ALDH1A1 (0.37) RAB9ANPC1SMN1; SMN2MAPTHPGD
SCHEMBL14242797 0.73 HDAC3 (0.46) NPC1CASP3NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
EP-4006016-A2 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2022-06-01 — — EP disclosed
EP-4006016-A2 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2022-06-01 — — EP disclosed
US-11059836-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2021-07-13 — — US disclosed
US-10907197-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2021-02-02 — — US disclosed
EP-3190888-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2020-06-10 — — EP disclosed
EP-3190888-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2020-06-10 — — EP disclosed
US-20170292150-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-10-12 — — US disclosed
US-20170292150-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-10-12 — — US disclosed
US-20170292150-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-10-12 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed
WO-2016033460-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 PBRM1 1021/4885GRM5 1486/4885RAB9A 1100/4885
US-11059836-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 PBRM1 1021/4885GRM5 1486/4885RAB9A 1100/4885
US-10907197-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 PBRM1 1087/4885GRM5 1815/4885RAB9A 993/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 PBRM1 1087/4885GRM5 1815/4885RAB9A 993/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 PBRM1 1021/4885GRM5 1486/4885RAB9A 1100/4885
US-20170292150-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 PBRM1 1087/4885GRM5 1815/4885RAB9A 993/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.