Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17548685 | 0.89 | CHRNB2 (0.56) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL28674730 | 0.83 | CHRNB2 (0.59) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL28987798 | 0.83 | CHRNB2 (0.58) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL5409935 | 0.82 | CHRNB2 (0.60) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL31091563 | 0.80 | CHRNB2 (0.59) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| Cyanide SCHEMBL28564062 | 0.80 | CHRNB2 (0.52) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL19734471 | 0.79 | CHRNB2 (0.55) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL5465366 | 0.79 | CHRNB2 (0.54) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL7089878 | 0.77 | CHRNB2 (0.55) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 | |
| SCHEMBL19734470 | 0.75 | CHRNB2 (0.54) | CHRNB2CHRNA7CHRNA4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745266-B2 | Indoline alkaloid compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160060219-A1 | INDOLINE ALKALOID COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060219-A1 | INDOLINE ALKALOID COMPOUNDS | INMT, IDO1, SRM | CHRNB2 2503/4885CHRNA7 1139/4885CHRNA4 1585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.