Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097366 | 0.85 | PIK3CD (0.47) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL8095121 | 0.79 | PIK3CD (0.43) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL740070 | 0.73 | PIK3CA (0.64) | PIK3CA | |
| SCHEMBL8091234 | 0.73 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL8204669 | 0.71 | KMT2A (0.45) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8214220 | 0.71 | PIK3CA (0.48) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8099045 | 0.70 | MAPT (0.39) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL8095008 | 0.69 | CA1 (0.53) | ALDH1A1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL1755671 | 0.69 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL8083334 | 0.69 | CA1 (0.41) | ALDH1A1L3MBTL1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176238-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |