Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | DDX3X | O00571 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17557161 | 0.77 | TTR (0.40) | KMT2AMEN1MAPTDDX3XALDH1A1 | |
| SCHEMBL11647391 | 0.76 | LMNA (0.48) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL2007744 | 0.76 | KMT2A (0.56) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL2009412 | 0.75 | ALDH1A1 (0.55) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL31090824 | 0.74 | CRHBP (0.58) | PARP1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL3184724 | 0.74 | CRHBP (0.58) | PARP1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10956293 | 0.73 | ALDH1A1 (0.50) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL14956674 | 0.71 | KMT2A (0.56) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL14956481 | 0.71 | KMT2A (0.51) | KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL63933 | 0.71 | KMT2A (0.70) | KMT2AMEN1CA1CA2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220289744-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2022-09-15 | — | — | US | disclosed |
| US-11279701-B2 | Immunomodulators and immunomodulator conjugates | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2022-03-22 | — | — | US | disclosed |
| US-20200325136-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-10-15 | — | — | US | disclosed |
| US-10730871-B2 | Immunomodulators and immunomodulator conjugates | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-08-04 | — | — | US | disclosed |
| US-9884866-B2 | Immunomodulators and immunomodulator conjugates | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-02-06 | — | — | US | disclosed |
| US-20170217960-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2017-08-03 | — | — | US | disclosed |
| US-20160068533-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2016-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730871-B2 | Immunomodulators and immunomodulator conjugates | CD40, CD47, FCGRT | PARP1 955/4885KMT2A 2234/4885MEN1 2185/4885 |
| US-20220289744-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | CD47, IL2, ICOS | PARP1 4248/4885KMT2A 1405/4885MEN1 3022/4885 |
| US-20160068533-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | CD40, CD47, FCGRT | PARP1 955/4885KMT2A 2234/4885MEN1 2185/4885 |
| US-11279701-B2 | Immunomodulators and immunomodulator conjugates | IL2, CD47, FCGRT | PARP1 3172/4885KMT2A 2100/4885MEN1 2321/4885 |
| US-20170217960-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | CD47, CD40, HLA-DRB1 | PARP1 929/4885KMT2A 2050/4885MEN1 2107/4885 |
| US-20200325136-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | IL2, CD47, FCGRT | PARP1 3172/4885KMT2A 2100/4885MEN1 2321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.