Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | ABL2 | P42684 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19397776 | 1.00 | FBP1 (0.72) | FBP1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL17558901 | 1.00 | FBP1 (0.72) | FBP1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL8628464 | 0.88 | FBP1 (0.64) | FBP1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL1127238 | 0.84 | FBP1 (1.00) | FBP1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL1032131 | 0.84 | FBP1 (1.00) | FBP1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL1749791 | 0.84 | FBP1 (1.00) | FBP1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL11166829 | 0.81 | FBP1 (0.62) | FBP1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL11166826 | 0.81 | FBP1 (0.62) | FBP1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL4801310 | 0.77 | AKR1C3 (0.67) | ALDH1A1MAPTKMT2ALMNAHTR6 | |
| SCHEMBL8039241 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2ALMNAHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189049-B1 | PHTHALAZINE DERIVATIVES OF FORMULA (I) AS PCAF AND GCN5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2024-03-20 | — | — | EP | disclosed |
| CN-107074823-B | Therapeutic compounds and uses thereof | 基因泰克公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-107074824-B | Phthalazine derivatives of formula (I) as PCAF and GCN5 inhibitors for the treatment of cancer | 基因泰克公司 | 2021-01-08 | — | — | CN | disclosed |
| EP-3189046-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| US-10358437-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-07-23 | — | — | US | disclosed |
| US-10316023-B2 | — | — | 2019-06-11 | — | — | US | disclosed |
| US-10155764-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC (US) | 2018-12-18 | — | — | US | disclosed |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170275289-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-09-28 | — | — | US | disclosed |
| EP-3189046-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2017-07-12 | — | — | EP | disclosed |
| EP-3189049-A1 | PHTHALAZINE DERIVATIVES OF FORMULA (I) AS PCAF AND GCN5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036954-A1 | PHTHALAZINE DERIVATIVES OF FORMULA (I) AS PCAF AND GCN5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2016-03-10 | — | — | WO | disclosed |
| WO-2016036873-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316023-B2 | — | PKD1, NHERF1, PCSK6 | FBP1 1199/4885ALDH1A1 1008/4885MAPT 1431/4885 |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | PKD1, NHERF1, HDAC10 | FBP1 1755/4885ALDH1A1 782/4885MAPT 1830/4885 |
| US-20170275289-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | HDAC10, HDAC6, HDAC1 | FBP1 2329/4885ALDH1A1 2604/4885MAPT 1601/4885 |
| US-10358437-B2 | Therapeutic compounds and uses thereof | PKD1, NHERF1, HDAC10 | FBP1 1755/4885ALDH1A1 782/4885MAPT 1830/4885 |
| US-10155764-B2 | Therapeutic compounds and uses thereof | HDAC10, HDAC6, HDAC1 | FBP1 2329/4885ALDH1A1 2604/4885MAPT 1601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.