Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | CES2 | O00748 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16205774 | 0.84 | ACHE (0.32) | GPR88 | |
| SCHEMBL17567262 | 0.79 | L3MBTL1 (0.48) | L3MBTL1 | |
| SCHEMBL16197714 | 0.79 | CA14 (0.34) | GPR88L3MBTL1 | |
| SCHEMBL16197719 | 0.79 | CA14 (0.34) | GPR88L3MBTL1 | |
| SCHEMBL16205781 | 0.78 | PDK2 (0.32) | GPR88 | |
| SCHEMBL21302057 | 0.77 | CTSK (0.33) | — | |
| SCHEMBL17203563 | 0.76 | CTSK (0.32) | GPR88 | |
| SCHEMBL16205764 | 0.76 | CTSK (0.32) | GPR88 | |
| SCHEMBL3161597 | 0.75 | CA14 (0.41) | — | |
| SCHEMBL21444891 | 0.74 | CTSK (0.33) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160068566-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | PIERRE FABRE MEDICAMENT (FR) | 2016-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068566-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | NR1H4, HCAR3, VDR | GPR88 437/4885L3MBTL1 3222/4885CES2 4452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.