Sugi Predict

Sugi Predict / Compounds / SCHEMBL17574201

SCHEMBL17574201

SCHEMBL17574201

O=C(N/N=C/c1cccc(C(F)(F)F)c1)N/N=C/c1cccc(C(F)(F)F)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RECQL P46063 1/20 0.74
▸ KDM4E B2RXH2 4/20 0.69
▸ KMT2A Q03164 7/20 0.67
▸ MAPT P10636 7/20 0.67
▸ MEN1 O00255 5/20 0.67
▸ HTT P42858 3/20 0.67
▸ GFER P55789 1/20 0.62
▸ NPC1 O15118 3/20 0.61
▸ RAB9A P51151 3/20 0.61
▸ GALR3 O60755 1/20 0.56
▸ XBP1 P17861 1/20 0.56
▸ MAPK1 P28482 1/20 0.56
▸ LMNA P02545 2/20 0.54
▸ GAA P10253 2/20 0.54
▸ ALDH1A1 P00352 1/20 0.54
▸ HPGD P15428 1/20 0.54
▸ POLB P06746 4/20 0.53
▸ SMN1; SMN2 Q16637 3/20 0.52
▸ ALPL P05186 1/20 0.51
▸ ALPI P09923 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17560993 1.00 RECQL (0.74) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL19434691 0.91 RECQL (0.71) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL17067806 0.91 RECQL (0.67) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL19434693 0.91 RECQL (0.71) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL19441401 0.90 RECQL (0.66) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL19449614 0.88 RECQL (0.80) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL31043533 0.88 RECQL (0.80) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL17560900 0.88 RECQL (0.80) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL19441400 0.88 RECQL (0.63) RECQLKDM4EKMT2AMAPTMEN1
SCHEMBL19449680 0.84 RECQL (0.66) RECQLKDM4EKMT2AMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11566012-B2 Methods for treating protozoan infections NEOCULI PTY LTD (AU) 2023-01-31 — — US disclosed
EP-3960729-A1 COMPOUNDS AND METHODS OF TREATING INFECTIONS Neoculi Pty Ltd (AU) 2022-03-02 — — EP disclosed
EP-2991968-B1 COMPOUNDS AND METHODS OF TREATING INFECTIONS NEOCULI PTY LTD (AU) 2021-11-10 — — EP disclosed
US-20210009552-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2021-01-14 — — US disclosed
US-10829468-B2 Methods for treating protozoan infections NEOCULI PTY LTD. (AU) 2020-11-10 — — US disclosed
US-20200290990-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2020-09-17 — — US disclosed
US-10752606-B2 Methods for treating protozoan infections NEOCULI PTY LTD. (AU) 2020-08-25 — — US disclosed
US-20200102287-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2020-04-02 — — US disclosed
US-10562880-B2 Methods for treating protozoan infections NEOCULI PTY LTD. (AU) 2020-02-18 — — US disclosed
US-20190330178-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2019-10-31 — — US disclosed
US-10392363-B2 Methods for treating protozoan infections NEOCULI PTY LTD. (AU) 2019-08-27 — — US disclosed
US-10370341-B2 Compounds and methods of treating infections NEOCULI PTY LTD (AU) 2019-08-06 — — US disclosed
US-20190084941-A1 COMPOUNDS AND METHODS OF TREATING INFECTIONS NEOCULI PTY LTD (AU) 2019-03-21 — — US disclosed
US-20170291886-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2017-10-12 — — US disclosed
WO-2016033635-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS NEOCULI PTY LTD (AU) 2016-03-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190084941-A1 COMPOUNDS AND METHODS OF TREATING INFECTIONS ELANE, IL1A, IL1B RECQL 374/4885KDM4E 3245/4885KMT2A 3325/4885
US-11566012-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-20200290990-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-10370341-B2 Compounds and methods of treating infections ELANE, IL1A, IL1B RECQL 374/4885KDM4E 3245/4885KMT2A 3325/4885
US-20210009552-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-20170291886-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-20200102287-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-20190330178-A1 METHODS FOR TREATING PROTOZOAN INFECTIONS DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-10829468-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-10562880-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-10752606-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885
US-10392363-B2 Methods for treating protozoan infections DPM1, ABCB11, PIGS RECQL 586/4885KDM4E 3521/4885KMT2A 2912/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.