Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648618 | 0.74 | KDM4E (0.49) | PDE10AMEN1ALDH1A1HTTKMT2A | |
| SCHEMBL3594952 | 0.74 | KDM4E (0.49) | PDE10AMEN1ALDH1A1HTTKMT2A | |
| SCHEMBL30945296 | 0.73 | CLK1 (0.51) | MEN1ALDH1A1HTTKMT2AEGFR | |
| SCHEMBL17574483 | 0.72 | MEN1 (0.38) | MAOBPDE10AMEN1ALDH1A1HTT | |
| SCHEMBL1460808 | 0.71 | MAOB (0.42) | MAOBPDE10AMEN1ALDH1A1HTT | |
| SCHEMBL15644331 | 0.69 | NUDT1 (0.35) | MAOBPDE10AKMT2ALMNAKDM4E | |
| SCHEMBL3402830 | 0.68 | KDM4E (0.45) | MAOBMEN1ALDH1A1HTTKMT2A | |
| SCHEMBL29790801 | 0.67 | HTR1A (0.43) | MEN1KMT2AKDM4EMAPTEGFR | |
| SCHEMBL14760387 | 0.67 | KDM4E (0.45) | MEN1ALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL21895406 | 0.67 | IDO1 (0.40) | LMNAKDM4EMAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3461825-B1 | NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USES | C&C RES LAB (KR) | 2023-06-07 | — | — | EP | claimed |
| US-9284335-B2 | Substituted pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines, pyrido[2,3-e][1,2,4]triazolo[1,5-c]pyrimidines and/or [1,2,4]triazolo[1,5-c]pteridines for treatment of central nervous system diseases and disorders | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2016-03-15 | — | — | US | disclosed |