Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21895649 | 0.82 | ALDH1A1 (0.57) | TRPV4ALDH1A1MCL1TSHRKDM4E | |
| SCHEMBL2244585 | 0.74 | TRPV4 (0.40) | TRPV4ALDH1A1MCL1TSHRKDM4E | |
| SCHEMBL29386495 | 0.73 | MCL1 (0.55) | TRPV4ALDH1A1MCL1TSHRL3MBTL1 | |
| SCHEMBL198172 | 0.73 | MCL1 (0.55) | TRPV4ALDH1A1MCL1TSHRL3MBTL1 | |
| SCHEMBL4817991 | 0.72 | ALDH1A1 (0.58) | ALDH1A1TSHRKMT2A | |
| SCHEMBL4818010 | 0.72 | ALDH1A1 (0.58) | ALDH1A1TSHRKMT2A | |
| SCHEMBL7124035 | 0.71 | POLB (0.47) | TRPV4ALDH1A1MCL1L3MBTL1KDM4E | |
| SCHEMBL10540391 | 0.71 | HSD11B1 (0.47) | TRPV4ALDH1A1TSHRL3MBTL1HPGD | |
| SCHEMBL12031543 | 0.69 | CYP3A4 (0.50) | TRPV4ALDH1A1MCL1TSHRL3MBTL1 | |
| SCHEMBL1060711 | 0.69 | TRPV4 (0.44) | TRPV4ALDH1A1MCL1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547655-B1 | ARYLSULFONAMIDE CCR3 ANTAGONISTS | AXIKIN PHARMACEUTICALS INC (US) | 2016-03-09 | — | — | EP | disclosed |