Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15283553 | 0.83 | CIT (0.44) | AAK1ABL1HTTMKNK1MKNK2 | |
| SCHEMBL15283326 | 0.78 | AAK1 (0.47) | AAK1ABL1MKNK1MKNK2IRAK4 | |
| SCHEMBL15283552 | 0.75 | CTSB (0.44) | AAK1ABL1 | |
| SCHEMBL25043755 | 0.75 | PTGS1 (0.43) | HTTSLC22A12 | |
| SCHEMBL17580433 | 0.73 | HTT (0.47) | HTT | |
| SCHEMBL15507823 | 0.71 | TTK (0.55) | MKNK1MKNK2CDK2DYRK1AERN1 | |
| SCHEMBL17580555 | 0.70 | SYK (0.38) | MKNK1MKNK2 | |
| SCHEMBL15507908 | 0.70 | LRRK2 (0.52) | PAX8GAKHTTMKNK1MKNK2 | |
| SCHEMBL17313489 | 0.69 | BRD4 (0.45) | AAK1ABL1MKNK1MKNK2MAP4K4 | |
| SCHEMBL17580583 | 0.69 | DRD2 (0.40) | GAKHTTERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |