Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15283617 | 0.84 | DRD2 (0.38) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL15283626 | 0.80 | HSD17B10 (0.39) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL15283575 | 0.77 | SIRT6 (0.42) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL28436551 | 0.72 | CHRM5 (0.36) | HTR2ASIGMAR1 | |
| SCHEMBL17313486 | 0.71 | CHRM5 (0.38) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15507823 | 0.71 | TTK (0.55) | ERN1TTK | |
| SCHEMBL15283283 | 0.70 | EGFR (0.42) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL17580433 | 0.70 | HTT (0.47) | HTT | |
| SCHEMBL17580555 | 0.69 | SYK (0.38) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL17580381 | 0.69 | AAK1 (0.41) | GAKERN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |