Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18300032 | 0.86 | TTK (0.43) | KEAP1TTKKMT2ASCN4AJMJD6 | |
| SCHEMBL15507823 | 0.79 | TTK (0.55) | TTKMKNK1MKNK2 | |
| SCHEMBL15283278 | 0.76 | KEAP1 (0.50) | SYKKEAP1KMT2ASCN4AJMJD6 | |
| SCHEMBL15283609 | 0.73 | XDH (0.43) | SYKKEAP1KMT2ASCN4AJMJD6 | |
| SCHEMBL4188651 | 0.73 | PDE4D (0.35) | KMT2ASCN4AUSP30KCNH2 | |
| SCHEMBL22710175 | 0.72 | CYP19A1 (0.45) | KEAP1KMT2ASCN4AJMJD6CYP19A1 | |
| SCHEMBL17580571 | 0.71 | P2RX3 (0.41) | KMT2ACYP19A1DRD2HTR2AHTR2C | |
| SCHEMBL17580506 | 0.71 | HPGD (0.37) | KMT2ACYP19A1P2RX3BRPF1 | |
| SCHEMBL17580381 | 0.70 | AAK1 (0.41) | MKNK1MKNK2 | |
| SCHEMBL17580433 | 0.70 | HTT (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |