Sugi Predict

Sugi Predict / Compounds / SCHEMBL17586285

SCHEMBL17586285

SCHEMBL17586285

CN(C(=O)OC(C)(C)C)C12CC(C1)C2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 2/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ ASGR1 P07306 1/20 0.35
▸ HSD11B1 P28845 2/20 0.33
▸ EPHX2 P34913 1/20 0.33
▸ USP2 O75604 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ GRIN2D O15399 2/20 0.32
▸ GRIN3B O60391 2/20 0.32
▸ GRIN1 Q05586 2/20 0.32
▸ GRIN2A Q12879 2/20 0.32
▸ GRIN2B Q13224 2/20 0.32
▸ GRIN2C Q14957 2/20 0.32
▸ GRIN3A Q8TCU5 2/20 0.32
▸ SMN1; SMN2 Q16637 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL140072 0.92 MAPK1 (0.44) MAPK1MEN1KMT2AHSD11B1EPHX2
SCHEMBL31639949 0.81 MEN1 (0.34) MAPK1MEN1KMT2AASGR1EPHX2
SCHEMBL25687114 0.79 HSD11B1 (0.35) MAPK1MEN1KMT2AHSD11B1USP2
SCHEMBL28922068 0.78 SMN1; SMN2 (0.37) MAPK1MEN1KMT2AASGR1EPHX2
SCHEMBL15279336 0.77 MEN1 (0.44) MAPK1MEN1KMT2AHSD11B1EPHX2
SCHEMBL137006 0.77 MEN1 (0.44) MAPK1MEN1KMT2AHSD11B1EPHX2
SCHEMBL17586292 0.76 ASGR1 (0.32) ASGR1TSHRHSD17B10SMN1; SMN2HDAC1
SCHEMBL23906171 0.76 ASGR1 (0.35) MAPK1MEN1KMT2AASGR1NFKB1
SCHEMBL13387122 0.75 MEN1 (0.40) MAPK1MEN1KMT2AEPHX2NFKB1
SCHEMBL1854491 0.75 SMN1; SMN2 (0.39) MAPK1MEN1KMT2AHSD11B1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025016323-A1 PROTEIN ARGINASE METHYLTRANSFERASE-5 INHIBITOR AND MEDICAL USE THEREOF 江苏亚虹医药科技股份有限公司 2025-01-23 — — WO disclosed
US-10975035-B2 Bicyclic compounds RECURIUM IP HOLDINGS, LLC (US) 2021-04-13 — — US disclosed
US-20190233377-A1 BICYCLIC COMPOUNDS Zeno Royalties & Milestones, LLC 2019-08-01 — — US disclosed
US-10308609-B2 Bicyclic compounds Zeno Royalties & Milestones, LLC (US) 2019-06-04 — — US disclosed
US-20160075654-A1 BICYCLIC COMPOUNDS RECURIUM IP HOLDINGS, LLC 2016-03-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190233377-A1 BICYCLIC COMPOUNDS OPRK1, OPRM1, OPRL1 MAPK1 4411/4885MEN1 2548/4885KMT2A 3792/4885
US-20160075654-A1 BICYCLIC COMPOUNDS OPRK1, OPRM1, OPRL1 MAPK1 4411/4885MEN1 2548/4885KMT2A 3792/4885
US-10975035-B2 Bicyclic compounds OPRK1, OPRM1, OPRL1 MAPK1 4411/4885MEN1 2548/4885KMT2A 3792/4885
US-10308609-B2 Bicyclic compounds OPRK1, OPRM1, OPRL1 MAPK1 4411/4885MEN1 2548/4885KMT2A 3792/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.