Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dioxane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA4 | P22748 | 3/20 | 0.40 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10990881 | 0.96 | CA4 (0.43) | TTRCA1CA12CA9CA4 | |
| Bicarbonate SCHEMBL10990882 | 0.96 | — | — | |
| Dioxane SCHEMBL1045521 | 0.92 | TTR (0.46) | TTRCA1CA12CA9CA4 | |
| Dioxane SCHEMBL28141413 | 0.92 | TTR (0.46) | TTRCA1CA12CA9CA4 | |
| Bicarbonate SCHEMBL28325709 | 0.92 | CA4 (0.40) | TTRCA1CA12CA9CA4 | |
| Dioxane SCHEMBL3328111 | 0.92 | TTR (0.46) | TTRCA1CA12CA9CA4 | |
| Dioxane SCHEMBL27496812 | 0.89 | TTR (0.43) | TTRCA1CA12CA9CA4 | |
| Dioxane SCHEMBL10803588 | 0.89 | SMN1; SMN2 (0.43) | TTRCA1CA12CA9CA4 | |
| Tetrahydrofuran SCHEMBL11210402 | 0.86 | ALDH1A1 (0.53) | TTRCA1CA12CA9CA4 | |
| Dioxane SCHEMBL13835212 | 0.86 | CA1 (0.60) | TTRCA1CA12CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119059967-A | Diaryl amine compound with affinity with Tau protein, and preparation method and application thereof | 北京师范大学 | 2024-12-03 | — | — | CN | disclosed |
| EP-3746451-B1 | BENZYL-, (PYRIDIN-3-YL)METHYL- OR (PYRIDIN-4-YL)METHYL-SUBSTITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2023-07-12 | — | — | EP | disclosed |
| US-11254688-B2 | Benzyl-, (pyridin-3-yl)methyl -or (pyridin-4-yl)-methyl-substituted oxadiazolopyridine derivatives as ghrelin O-acyl transferase (GOAT) inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-02-22 | — | — | US | disclosed |
| US-20210053985-A1 | BENZYL-, (PYRIDIN-3-YL)METHYL -OR (PYRIDIN-4-YL)-METHYL-SUBSTIITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-02-25 | — | — | US | disclosed |
| EP-3746451-A1 | BENZYL-, (PYRIDIN-3-YL)METHYL- OR (PYRIDIN-4-YL)METHYL-SUBSTITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2020-12-09 | — | — | EP | disclosed |
| WO-2019189766-A1 | NOVEL BIARYL AMIDE DERIVATIVE | 持田製薬株式会社 | 2019-10-03 | — | — | WO | disclosed |
| WO-2019149657-A1 | BENZYL-, (PYRIDIN-3-YL)METHYL- OR (PYRIDIN-4-YL)METHYL-SUBSTITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-08-08 | — | — | WO | disclosed |
| CN-107011273-A | The method of one kind synthesis amine of 6 iodine 3 (2,3 dichlorophenyl) pyrazine 2 | 无锡捷化医药科技有限公司 | 2017-08-04 | — | — | CN | disclosed |
| US-8852554-B2 | Radiolabelled PDE10 ligands | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-07 | — | — | US | disclosed |
| EP-2493513-B1 | RADIOLABELLED PDE10 LIGANDS | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-30 | — | — | EP | disclosed |
| US-20030139348-A1 | Low molecular weight peptidomimetic growth hormone secretagogues | GENENTECH, INC. | 2003-07-24 | — | — | US | disclosed |
| US-20020111461-A1 | LOW MOLECULAR WEIGHT PEPTIDOMIMETIC GROWTH HORMONE SECRETAGOGUES | SOMERS TODD C (US) | 2002-08-15 | — | — | US | disclosed |
| EP-1117677-A1 | LIGAND PRESENTING ASSEMBLY (LPA), METHOD OF PREPARATION AND USES THEREOF | Statens Serum Institut (DK) | 2001-07-25 | — | — | EP | disclosed |
| EP-0792289-B1 | LOW MOLECULAR WEIGHT PEPTIDOMIMETIC GROWTH HORMONE SECRETAGOGUES | GENENTECH INC (US) | 2000-07-12 | — | — | EP | disclosed |
| EP-0999220-A2 | Low molecular weight peptidomimetic growth hormone secretagogues | Genentech, Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| WO-2000018791-A1 | LIGAND PRESENTING ASSEMBLY (LPA), METHOD OF PREPARATION AND USES THEREOF | STATENS SERUM INSTITUT (DK) | 2000-04-06 | — | — | WO | disclosed |
| US-6034216-A | Low molecular weight peptidomimetic growth hormone secretagogues | GENENTECH INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-5798337-A | USED TO PROMOTE GROWTH IN MAMMALS EITHER ALONE OR IN COMBINATION WITH OTHER GROWTH PROMOTING COMPOUNDS | GENENTECH, INC. (US) | 1998-08-25 | — | — | US | disclosed |
| EP-0792289-A1 | LOW MOLECULAR WEIGHT PEPTIDOMIMETIC GROWTH HORMONE SECRETAGOGUES | GENENTECH, INC. (US) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015148-A2 | LOW MOLECULAR WEIGHT PEPTIDOMIMETIC GROWTH HORMONE SECRETAGOGUES | GENENTECH, INC. (US) | 1996-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139348-A1 | Low molecular weight peptidomimetic growth hormone secretagogues | GHSR, GHRHR, IGFBP1 | TTR 4227/4885CA1 3802/4885CA12 2458/4885 |
| US-20020111461-A1 | LOW MOLECULAR WEIGHT PEPTIDOMIMETIC GROWTH HORMONE SECRETAGOGUES | GHSR, GHRHR, IGFBP1 | TTR 4227/4885CA1 3802/4885CA12 2458/4885 |
| US-20210053985-A1 | BENZYL-, (PYRIDIN-3-YL)METHYL -OR (PYRIDIN-4-YL)-METHYL-SUBSTIITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | MBOAT4, GIPR, ADIPOR1 | TTR 1205/4885CA1 4480/4885CA12 4788/4885 |
| US-11254688-B2 | Benzyl-, (pyridin-3-yl)methyl -or (pyridin-4-yl)-methyl-substituted oxadiazolopyridine derivatives as ghrelin O-acyl transferase (GOAT) inhibitors | MBOAT4, ADIPOR1, GIPR | TTR 1266/4885CA1 4432/4885CA12 4769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.