Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980697 | 0.77 | S1PR4 (0.55) | RAB9AMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL12031808 | 0.77 | CHRNB2 (0.46) | RAB9AMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL1759055 | 0.74 | ALDH1A1 (0.48) | RAB9AMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2936738 | 0.74 | KDM4E (0.61) | RAB9AMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL15489133 | 0.70 | SLC18A3 (0.46) | MAPTKDM4ELMNASMN1; SMN2SLC18A3 | |
| SCHEMBL8536024 | 0.70 | S1PR1 (0.38) | RAB9AKDM4ELMNASMN1; SMN2SLC18A3 | |
| SCHEMBL10458360 | 0.69 | HTR1B (0.53) | MAPTKDM4E | |
| SCHEMBL10458074 | 0.69 | LMNA (0.52) | RAB9AMAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10750620 | 0.68 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL22111020 | 0.67 | L3MBTL1 (0.60) | RAB9AMAPTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493513-A1 | RADIOLABELLED PDE10 LIGANDS | Janssen Pharmaceutica, N.V. (BE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051324-A1 | RADIOLABELLED PDE10 LIGANDS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |