Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593165 | 0.89 | TRIM24 (0.49) | ADRB2ADRB1ADRB3SMN1; SMN2POLB | |
| SCHEMBL17593159 | 0.74 | MAPT (0.48) | SMN1; SMN2POLBMAPTTSHRMEN1 | |
| SCHEMBL17593059 | 0.70 | ALDH1A1 (0.39) | SMN1; SMN2POLBMAPTTSHRMEN1 | |
| SCHEMBL17592991 | 0.68 | LMNA (0.38) | ADRB2ADRB1SMN1; SMN2POLBMAPT | |
| SCHEMBL3505126 | 0.66 | PKM (0.61) | SMN1; SMN2MAPTTRIM24TSHRMEN1 | |
| SCHEMBL12783378 | 0.64 | HPGD (0.58) | ADRB2ADRB1ADRB3SMN1; SMN2MAPT | |
| SCHEMBL11947873 | 0.63 | SCN3A (0.59) | SCN3A | |
| SCHEMBL14756785 | 0.63 | TRIM24 (0.83) | ADRB2ADRB1ADRB3SMN1; SMN2TRIM24 | |
| SCHEMBL17593128 | 0.63 | HDAC3 (0.56) | ADRB3SMN1; SMN2TSHR | |
| SCHEMBL1222694 | 0.63 | ALOX15 (0.61) | SMN1; SMN2POLBMAPTTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |