Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | NAMPT | P43490 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13453565 | 0.91 | POLB (0.66) | POLBMEN1KMT2AGPR27KDM4E | |
| SCHEMBL12197846 | 0.83 | GRM4 (0.85) | POLBMEN1KMT2AGPR27KDM4E | |
| SCHEMBL17593181 | 0.82 | KMT2A (0.92) | POLBMEN1KMT2AGPR27SMN1; SMN2 | |
| SCHEMBL10978860 | 0.80 | RAB9A (0.86) | MEN1KMT2ALMNASMN1; SMN2RXFP1 | |
| SCHEMBL547543 | 0.80 | KDM4E (1.00) | POLBMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7512145 | 0.79 | LMNA (0.70) | POLBMEN1KMT2AGPR27KDM4E | |
| SCHEMBL13453572 | 0.78 | MEN1 (0.80) | POLBMEN1KMT2AKDM4ELMNA | |
| SCHEMBL27180378 | 0.77 | GPR27 (0.72) | POLBMEN1KMT2AGPR27KDM4E | |
| SCHEMBL328332 | 0.77 | RXFP1 (0.68) | POLBMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL5560159 | 0.77 | KDM4E (0.71) | POLBMEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |