Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 7/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.30 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.30 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.30 |
| ▸ | ADH5 | P11766 | 3/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17595373 | 0.86 | AURKA (0.34) | AURKATTKAURKBINCENPERN1 | |
| SCHEMBL17597598 | 0.84 | USP7 (0.41) | KDM5BBRD4 | |
| SCHEMBL14746098 | 0.80 | AURKA (0.38) | AURKATTKAURKBINCENPERN1 | |
| SCHEMBL17597694 | 0.80 | PTGER3 (0.31) | PDE3BPDE3A | |
| SCHEMBL17594871 | 0.79 | ALDH1A1 (0.39) | EZH2PDE3BPDE3A | |
| SCHEMBL17595195 | 0.79 | KDM5A (0.32) | PDE3BPDE3AKDM4EKDM5AKDM5B | |
| SCHEMBL17594971 | 0.79 | LMNA (0.39) | PDE3BPDE3A | |
| SCHEMBL14741179 | 0.78 | CREBBP (0.40) | AURKATTKAURKBINCENPMAPK1 | |
| SCHEMBL17595256 | 0.78 | PDE3B (0.35) | PDE3BPDE3AKDM4E | |
| SCHEMBL17597217 | 0.77 | MTNR1A (0.33) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |