Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 5/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.58 |
| ▸ | JUN | P05412 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172939 | 0.84 | ALDH1A1 (0.71) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL29392394 | 0.84 | ALDH1A1 (0.71) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL5877571 | 0.81 | CYP1A1 (0.69) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL2121298 | 0.81 | CYP1A1 (0.69) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL5252418 | 0.79 | CYP1A1 (0.66) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL1547729 | 0.78 | CYP1A1 (0.63) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL11874684 | 0.76 | CYP1A1 (0.79) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL11874692 | 0.76 | CYP1A1 (0.79) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL1792533 | 0.76 | CYP1A1 (0.61) | CYP1A1CYP1B1CYP1A2NFE2L2JUN | |
| SCHEMBL6631188 | 0.76 | CYP1A1 (0.61) | CYP1A1CYP1B1CYP1A2NFE2L2JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981994-B2 | Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2018-05-29 | — | — | US | disclosed |
| EP-2970204-B1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC FOUND FOR RES DEV (US) | 2018-03-28 | — | — | EP | disclosed |
| US-20170121353-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND MEHTODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2017-05-04 | — | — | US | disclosed |
| US-9556207-B2 | Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150057247-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2015-02-26 | — | — | US | disclosed |
| US-8921401-B2 | Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140274950-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | MEDICAL UNIVERSITY OF SOUTH CAROLINA (US) | 2014-09-18 | — | — | US | disclosed |
| US-8765728-B2 | [1,5]-diazocin derivatives | MELLITECH (FR) | 2014-07-01 | — | — | US | disclosed |
| EP-2501685-A1 | [1,5]-DIAZOCIN DERIVATIVES | Mellitech (FR) | 2012-09-26 | — | — | EP | disclosed |
| US-20120225892-A1 | [1,5]-Diazocin Derivatives | MELLITECH (FR) | 2012-09-06 | — | — | US | disclosed |
| WO-2011058193-A1 | [1,5]-DIAZOCIN DERIVATIVES | MELLITECH (FR) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121353-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND MEHTODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | PPARD, ACHE, PRNP | CYP1A1 208/4885CYP1B1 77/4885CYP1A2 145/4885 |
| US-20140274950-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | PPARG, PPARD, PC | CYP1A1 355/4885CYP1B1 131/4885CYP1A2 243/4885 |
| US-20150057247-A1 | PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS | PPARG, PPARD, PC | CYP1A1 355/4885CYP1B1 131/4885CYP1A2 243/4885 |
| US-20120225892-A1 | [1,5]-Diazocin Derivatives | IAPP, INSR, GLP1R | CYP1A1 2119/4885CYP1B1 907/4885CYP1A2 2743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.