Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | RORA | P35398 | 1/20 | 0.44 |
| ▸ | RORB | Q92753 | 1/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599343 | 0.88 | KEAP1 (0.46) | PFKFB3KEAP1KMT2APFKFB4MCL1 | |
| SCHEMBL17599390 | 0.87 | KEAP1 (0.56) | PFKFB3KEAP1KMT2APFKFB4MCL1 | |
| SCHEMBL17613382 | 0.79 | PIK3CG (0.42) | PIK3CGPIK3CAPIK3CDPIK3CBRORC | |
| SCHEMBL2157974 | 0.79 | NPSR1 (0.54) | PIK3CGPIK3CAPIK3CDPIK3CBRORC | |
| SCHEMBL3566136 | 0.78 | SLC16A3 (0.57) | PIK3CGPIK3CAPIK3CDPIK3CBRORC | |
| SCHEMBL17599301 | 0.77 | KMT2A (0.48) | PFKFB3KMT2ACKS1BSKP2MCL1 | |
| SCHEMBL3552051 | 0.76 | SLC16A3 (0.53) | PIK3CGPIK3CAPIK3CDPIK3CBRORC | |
| SCHEMBL17599388 | 0.76 | ACLY (0.48) | KMT2AMCL1 | |
| SCHEMBL3807331 | 0.76 | PIK3CG (0.47) | PIK3CGPIK3CAPIK3CDPIK3CBRORC | |
| SCHEMBL17599312 | 0.75 | KEAP1 (0.61) | KEAP1KMT2ACKS1BSKP2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |