Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PFKFB4 | Q16877 | 4/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599390 | 0.91 | KEAP1 (0.56) | KEAP1KMT2APFKFB4MCL1PFKFB3 | |
| SCHEMBL17599331 | 0.88 | PIK3CG (0.45) | KEAP1KMT2APFKFB4MCL1PFKFB3 | |
| SCHEMBL17599341 | 0.84 | FABP4 (0.43) | KEAP1KMT2APFKFB4HSD11B1PFKFB3 | |
| SCHEMBL17599388 | 0.79 | ACLY (0.48) | KMT2AMCL1BRD4ACLYAKR1C3 | |
| SCHEMBL17599312 | 0.79 | KEAP1 (0.61) | KEAP1KMT2AMCL1 | |
| SCHEMBL17599401 | 0.78 | PFKFB4 (0.69) | KEAP1PFKFB4PFKFB3 | |
| SCHEMBL17599329 | 0.78 | KMT2A (0.55) | KEAP1KMT2AMCL1BRD4ACLY | |
| SCHEMBL17599367 | 0.78 | PFKFB4 (0.47) | KEAP1KMT2APFKFB4MCL1PFKFB3 | |
| SCHEMBL17599327 | 0.78 | ACLY (0.61) | KMT2APFKFB4MCL1BRD4ACLY | |
| SCHEMBL17599382 | 0.77 | WDR5 (0.45) | KMT2AMCL1ACLYSERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |