Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA1 | P56199 | 3/20 | 0.56 |
| ▸ | WDR5 | P61964 | 1/20 | 0.51 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.49 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 2/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599340 | 0.92 | SLC16A3 (0.58) | ITGA1WDR5SERPINE1SLC16A3KMT2A | |
| SCHEMBL17599402 | 0.90 | BRD4 (0.52) | ITGA1WDR5KMT2AMEN1ACLY | |
| SCHEMBL17599404 | 0.88 | KMT2A (0.48) | WDR5SERPINE1SLC16A3KMT2AMEN1 | |
| SCHEMBL17599330 | 0.87 | WDR5 (0.47) | ITGA1WDR5KMT2AMEN1ACLY | |
| SCHEMBL17599379 | 0.86 | ACLY (0.54) | WDR5SLC16A3KMT2AMEN1ACLY | |
| SCHEMBL17599371 | 0.85 | KMT2A (0.51) | WDR5SLC16A3KMT2AMEN1ACLY | |
| SCHEMBL17599403 | 0.84 | WDR5 (0.49) | WDR5SLC16A3KMT2AMEN1SLC40A1 | |
| SCHEMBL17599353 | 0.84 | ACLY (0.58) | SERPINE1KMT2AACLYPTK2BKDM4E | |
| SCHEMBL17599310 | 0.83 | PTK2B (0.53) | WDR5KMT2AACLYPTK2BSMN1; SMN2 | |
| SCHEMBL17599406 | 0.82 | ACLY (0.58) | WDR5SERPINE1KMT2AMEN1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |