Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599379 | 0.89 | ACLY (0.54) | WDR5PTK2BKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL17599319 | 0.88 | ACLY (0.46) | WDR5PTK2BKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL17599371 | 0.87 | KMT2A (0.51) | WDR5PTK2BKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL17599368 | 0.85 | KDM4E (0.48) | WDR5PTK2BKDM4ETSHRPFKFB4 | |
| SCHEMBL17599404 | 0.84 | KMT2A (0.48) | WDR5FABP4L3MBTL1KMT2AACLY | |
| SCHEMBL17599340 | 0.84 | SLC16A3 (0.58) | WDR5PTK2BKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL17599360 | 0.84 | ITGA1 (0.56) | WDR5PTK2BKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL17599382 | 0.83 | WDR5 (0.45) | WDR5PTK2BKDM4ETSHRFABP4 | |
| SCHEMBL17599361 | 0.83 | KDM4E (0.43) | WDR5PTK2BKDM4ETSHRPFKFB4 | |
| SCHEMBL17599310 | 0.82 | PTK2B (0.53) | WDR5PTK2BKDM4ETSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |