Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 7/20 | 0.56 |
| ▸ | PFKFB4 | Q16877 | 6/20 | 0.56 |
| ▸ | CMA1 | P23946 | 8/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613337 | 0.89 | PFKFB3 (0.63) | PFKFB3PFKFB4CMA1KEAP1HTR6 | |
| SCHEMBL17599334 | 0.86 | PFKFB4 (0.41) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL17599401 | 0.78 | PFKFB4 (0.69) | PFKFB3PFKFB4CMA1KEAP1HTR6 | |
| SCHEMBL5621524 | 0.77 | PFKFB3 (0.70) | PFKFB3PFKFB4CMA1KEAP1NPSR1 | |
| SCHEMBL2912893 | 0.76 | CMA1 (0.82) | PFKFB3PFKFB4CMA1NPSR1L3MBTL1 | |
| SCHEMBL5620427 | 0.75 | CMA1 (0.85) | PFKFB3PFKFB4CMA1KEAP1HTR6 | |
| SCHEMBL17599375 | 0.75 | ACLY (0.49) | KEAP1 | |
| SCHEMBL16775639 | 0.74 | CMA1 (0.67) | PFKFB3PFKFB4CMA1NPSR1L3MBTL1 | |
| SCHEMBL17599438 | 0.74 | KEAP1 (0.80) | PFKFB3PFKFB4CMA1KEAP1HTR6 | |
| SCHEMBL5621183 | 0.73 | CMA1 (0.83) | PFKFB3PFKFB4CMA1KEAP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |