Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB4 | Q16877 | 5/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CMA1 | P23946 | 3/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599377 | 0.86 | PFKFB3 (0.56) | PFKFB4PFKFB3CMA1 | |
| SCHEMBL17599375 | 0.75 | ACLY (0.49) | KDM4EGLO1SLC40A1CKS1BSKP2 | |
| SCHEMBL17599357 | 0.75 | KDM4E (0.46) | KDM4EGLO1SLC40A1MMP2MMP9 | |
| SCHEMBL17613337 | 0.75 | PFKFB3 (0.63) | PFKFB4PFKFB3CMA1 | |
| SCHEMBL17599461 | 0.74 | KEAP1 (0.65) | KDM4ESLC40A1TDP1MMP2MMP9 | |
| SCHEMBL17599341 | 0.72 | FABP4 (0.43) | PFKFB4PFKFB3CMA1KMT2AALDH1A1 | |
| SCHEMBL17599395 | 0.71 | KDM4E (0.37) | KDM4EGLO1SLC40A1TDP1MEN1 | |
| SCHEMBL17599370 | 0.69 | ALDH1A1 (0.53) | KDM4EMEN1KMT2AALDH1A1GAA | |
| SCHEMBL17599349 | 0.68 | MEN1 (0.43) | KDM4EMEN1KMT2AALDH1A1GAA | |
| SCHEMBL17599385 | 0.67 | TSHR (0.47) | KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |