Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 3/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714338 | 0.86 | PTGIR (0.52) | PTGIRKMT2ARAB9AALDH1A1HTT | |
| SCHEMBL3653802 | 0.71 | MAP4K4 (0.36) | KMT2ARAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL15173773 | 0.70 | HCAR3 (0.38) | PTGIRKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2096920 | 0.69 | NPSR1 (0.54) | PTGIRKMT2ALMNARAB9ASMN1; SMN2 | |
| SCHEMBL59042 | 0.69 | PPARG (0.40) | LTC4SKMT2AGPBAR1MEN1 | |
| SCHEMBL17601641 | 0.69 | NPSR1 (0.38) | PTGIRKMT2ARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3655649 | 0.68 | RAB9A (0.36) | KMT2ALMNARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3646652 | 0.67 | KDM4E (0.42) | KMT2ARAB9ACYP3A4MEN1 | |
| SCHEMBL10949772 | 0.67 | KMT2A (0.44) | LTC4SKMT2ARAB9ASMN1; SMN2VNN1 | |
| SCHEMBL57851 | 0.67 | TRPM8 (0.43) | PTGIRKMT2ARAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | PTGIR 2680/4885BCL2A1 833/4885FFAR2 2359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.