Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 19/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30356579 | 1.00 | NR1H2 (0.54) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL23631434 | 0.89 | NR1H2 (0.54) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL15232130 | 0.87 | NR1H2 (0.53) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL31620901 | 0.84 | NR1H2 (0.55) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL23928895 | 0.82 | CCNB2 (0.41) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL13237432 | 0.82 | NR1H2 (0.41) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL4037148 | 0.81 | CYP2A6 (0.38) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL5713778 | 0.81 | NR1H2 (0.57) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL17022654 | 0.81 | NR1H2 (0.57) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL30711377 | 0.81 | NR1H2 (0.57) | NR1H2NR1H3CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118515699-A | Hirsutine alkaloid boric acid derivative and preparation method and application thereof | 中国海洋大学 | 2024-08-20 | — | — | CN | disclosed |
| CN-117986254-A | Hirsutine alkaloid derivative, and preparation method and application thereof | 中国海洋大学 | 2024-05-07 | — | — | CN | disclosed |
| US-20230212171-A1 | ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. | 2023-07-06 | — | — | US | disclosed |
| US-20230212171-A1 | ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. | 2023-07-06 | — | — | US | disclosed |
| CN-115811977-A | Allosteric EGFR inhibitors and methods of use thereof | 达纳-法伯癌症研究所股份有限公司 | 2023-03-17 | — | — | CN | disclosed |
| US-20210403470-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | WATKINS EDMOND BLAKE (US) | 2021-12-30 | — | — | US | disclosed |
| WO-2021252661-A1 | ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-12-16 | — | — | WO | disclosed |
| US-11117893-B2 | Methods for preparation of substituted pyridines and related novel compounds | UNION UNIVERSITY (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200095245-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | UNION UNIVERSITY | 2020-03-26 | — | — | US | disclosed |
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. | 2019-04-18 | — | — | US | disclosed |
| EP-3022177-B1 | INDOLE-3-CARBINOL DERIVATIVES | CADILA PHARMACEUTICALS LTD (IN) | 2018-03-28 | — | — | EP | disclosed |
| US-20170368051-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-12-28 | — | — | US | disclosed |
| US-9708258-B2 | Indole 3-carbinol derivatives | CADILA PHARMACEUTICALS, LTD. (IN) | 2017-07-18 | — | — | US | disclosed |
| US-9518022-B2 | Anti-HIV compounds | PROSETTA ANTIVIRAL INC. (US) | 2016-12-13 | — | — | US | disclosed |
| WO-2016100391-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. (US) | 2016-06-23 | — | — | WO | disclosed |
| US-20160168100-A1 | ANTI-HIV COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-16 | — | — | US | disclosed |
| US-20160159740-A1 | INDOLE-3-CARBINOL DERIVATIVES | CADILA PHARMACEUTICALS LTD. (IN) | 2016-06-09 | — | — | US | disclosed |
| EP-3022177-A1 | INDOLE-3-CARBINOL DERIVATIVES | Cadila Pharmaceuticals Ltd. (IN) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015008202-A1 | INDOLE-3-CARBINOL DERIVATIVES | CADILA PHARMACEUTICALS LIMITED (IN) | 2015-01-22 | — | — | WO | disclosed |
| WO-2011057959-A1 | INDOLE AND INDAZOLE DERIVATIVES AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | MAVS, EIF2AK2, POLRMT | NR1H2 2067/4885NR1H3 2029/4885CA12 4883/4885 |
| US-20210403470-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | WEE1, WEE2, THEM6 | NR1H2 4499/4885NR1H3 4343/4885CA12 2975/4885 |
| US-20160168100-A1 | ANTI-HIV COMPOUNDS | MAVS, SARS1, NFATC1 | NR1H2 837/4885NR1H3 614/4885CA12 4880/4885 |
| US-11117893-B2 | Methods for preparation of substituted pyridines and related novel compounds | NNMT, CYP4F3, AGPS | NR1H2 4602/4885NR1H3 4425/4885CA12 1945/4885 |
| US-20230212171-A1 | ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF | EGFR, ERBB2, ERBB3 | NR1H2 1965/4885NR1H3 1942/4885CA12 3949/4885 |
| US-20200095245-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | WEE1, WEE2, THEM6 | NR1H2 4499/4885NR1H3 4343/4885CA12 2975/4885 |
| US-20170368051-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | MAVS, EIF2AK2, POLRMT | NR1H2 2067/4885NR1H3 2029/4885CA12 4883/4885 |
| US-20160159740-A1 | INDOLE-3-CARBINOL DERIVATIVES | IDO1, IDO2, TPH1 | NR1H2 664/4885NR1H3 784/4885CA12 3035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.