Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760840 | 1.00 | MMP9 (0.54) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL1760825 | 0.90 | MMP2 (0.51) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL1760829 | 0.90 | MMP2 (0.51) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL3086045 | 0.84 | MMP2 (0.63) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL1760823 | 0.84 | MMP2 (0.46) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL1760822 | 0.84 | MMP2 (0.46) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL1760815 | 0.83 | MMP2 (0.54) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL1760826 | 0.83 | MMP2 (0.54) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL1760882 | 0.82 | MMP2 (0.45) | MMP9MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL14037540 | 0.82 | MMP2 (0.45) | MMP9MMP2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039465-B2 | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-7947850-B2 | Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones | INSPIRE PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100130572-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | LAMPE JOHN W | 2010-05-27 | — | — | US | disclosed |
| US-7666861-B2 | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| EP-1996192-A2 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | Inspire Pharmaceuticals, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| US-20080287683-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | DECAMP JONATHAN B | 2008-11-20 | — | — | US | disclosed |
| US-7414137-B2 | Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-08-19 | — | — | US | disclosed |
| CN-101160315-A | Cytoskeletal active compounds, composition and use | INSPIRE PHARMACEUTICALS INC (US) | 2008-04-09 | — | — | CN | disclosed |
| US-20080076735-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | CHATTEM INC. | 2008-03-27 | — | — | US | disclosed |
| US-7320974-B2 | Cytoskeletal active compounds, compositions and use | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1866316-A2 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | Inspire Pharmaceuticals, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| US-20070225504-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | INSPIRE PHARMACEUTICALS, INC. | 2007-09-27 | — | — | US | disclosed |
| WO-2007109786-A2 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | INSPIRE PHARMACEUTICALS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |
| WO-2006104897-A2 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | INSPIRE PHARMACEUTICALS, INC. (US) | 2006-10-05 | — | — | WO | disclosed |
| US-20060217427-A1 | Cytoskeletal active compounds, compositions and use | INSPIRE PHARMACEUTICALS, INC. | 2006-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225504-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | ACTR2, ACTR5, ACTR3 | MMP9 4859/4885MMP2 4269/4885MEN1 1636/4885 |
| US-20060217427-A1 | Cytoskeletal active compounds, compositions and use | RHOA, ACTB, ROCK1 | MMP9 3742/4885MMP2 2595/4885MEN1 3613/4885 |
| US-20080287683-A1 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES | ACTR2, ACTR5, ACTR3 | MMP9 4859/4885MMP2 4269/4885MEN1 1636/4885 |
| US-20100130572-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | RHOA, ACTB, ROCK1 | MMP9 3700/4885MMP2 2655/4885MEN1 3748/4885 |
| US-20080076735-A1 | CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE | RHOA, ACTB, ROCK1 | MMP9 3700/4885MMP2 2655/4885MEN1 3748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.