Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608370 | 0.91 | POLB (0.47) | POLBHRH1PTGER4RAB9AALDH1A1 | |
| SCHEMBL17624290 | 0.82 | HRH1 (0.45) | POLBHRH1RAB9AALDH1A1LMNA | |
| SCHEMBL17608582 | 0.77 | F2RL3 (0.45) | PTGER4RAB9AALDH1A1HDAC3HDAC1 | |
| SCHEMBL17608363 | 0.72 | CCNC (0.69) | CCNCCDK8NPC1RAB9AALDH1A1 | |
| SCHEMBL8607985 | 0.71 | LMNA (0.48) | POLBALDH1A1LMNA | |
| SCHEMBL17624218 | 0.71 | HSD11B1 (0.46) | POLBPTGER4HDAC3HDAC1HDAC2 | |
| SCHEMBL16127813 | 0.69 | GAA (0.52) | POLBPTGER4RAB9AALDH1A1 | |
| SCHEMBL31647362 | 0.69 | PTGER4 (0.58) | PTGER4HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL14977876 | 0.69 | F2RL3 (0.48) | PTGER4RAB9AALDH1A1HDAC3HDAC1 | |
| SCHEMBL24077087 | 0.68 | SMPD1 (0.72) | NPC1RAB9AALDH1A1LMNAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |