Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608370 | 0.86 | POLB (0.47) | GAARAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL16127813 | 0.82 | GAA (0.52) | F2RL3GAARAB9AMAPK10MEN1 | |
| SCHEMBL14977876 | 0.79 | F2RL3 (0.48) | F2RL3GAARAB9AMAPK10MEN1 | |
| SCHEMBL17608485 | 0.79 | ADRA1A (0.43) | GAAMEN1KMT2ASLC16A3MAPT | |
| SCHEMBL17608355 | 0.77 | CCNC (0.53) | RAB9AALDH1A1PTGER4HDAC3HDAC1 | |
| SCHEMBL1553851 | 0.76 | SLC22A12 (0.58) | F2RL3GAARAB9AMEN1KMT2A | |
| SCHEMBL17608644 | 0.75 | PTGER4 (0.51) | F2RL3GAARAB9AMEN1KMT2A | |
| SCHEMBL28569132 | 0.74 | FGFR1 (0.41) | ALDH1A1 | |
| SCHEMBL8687237 | 0.72 | SLC22A12 (0.44) | F2RL3GAARAB9AMAPK10MEN1 | |
| SCHEMBL12797648 | 0.72 | LOXL2 (0.64) | RAB9AMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |