Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608355 | 0.91 | CCNC (0.53) | POLBHRH1HSD11B1RAB9AALDH1A1 | |
| SCHEMBL17608582 | 0.86 | F2RL3 (0.45) | TP53MEN1KMT2AMAPTGAA | |
| SCHEMBL17624290 | 0.83 | HRH1 (0.45) | POLBHRH1MAPTRAB9AALDH1A1 | |
| SCHEMBL16127813 | 0.79 | GAA (0.52) | POLBMEN1KMT2AMAPTGAA | |
| SCHEMBL14977876 | 0.78 | F2RL3 (0.48) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL17608644 | 0.73 | PTGER4 (0.51) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL28569132 | 0.73 | FGFR1 (0.41) | HRH1ALDH1A1 | |
| SCHEMBL1553851 | 0.72 | SLC22A12 (0.58) | POLBMEN1KMT2AGAARAB9A | |
| SCHEMBL8607985 | 0.71 | LMNA (0.48) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL17624218 | 0.71 | HSD11B1 (0.46) | POLBHSD11B1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |