Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1216862 | 0.84 | CYP1A2 (0.51) | PTGER4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17624291 | 0.84 | ELANE (0.53) | PTGER4MCL1PTGDR2ELANENR1H2 | |
| SCHEMBL17608644 | 0.84 | PTGER4 (0.51) | PTGER4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17624218 | 0.83 | HSD11B1 (0.46) | PTGER4PTGDR2ELANEHDAC6 | |
| SCHEMBL17608697 | 0.81 | AR (0.43) | PTGER4PTGDR2ELANEF2RL3 | |
| SCHEMBL1214836 | 0.79 | ELANE (0.64) | PTGER4CYP1A2MCL1PTGDR2ELANE | |
| SCHEMBL17608381 | 0.76 | ELANE (0.46) | PTGER4CYP1A2CYP2D6MCL1PTGDR2 | |
| SCHEMBL30602811 | 0.75 | PTGDR2 (0.46) | PTGER4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14584194 | 0.74 | MCL1 (0.69) | PTGER4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3500587 | 0.71 | CYP1A2 (0.70) | PTGER4CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |