Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 10/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608449 | 0.84 | PTGER4 (0.51) | ELANEPTGDR2PTGER4F2RL3MCL1 | |
| SCHEMBL17624218 | 0.82 | HSD11B1 (0.46) | ELANEPTGDR2PTGER4 | |
| SCHEMBL1216862 | 0.81 | CYP1A2 (0.51) | ELANEPTGDR2PLA2G2APTGER4PTGER1 | |
| SCHEMBL17608697 | 0.81 | AR (0.43) | ELANEPTGDR2VNN1PTGER4F2RL3 | |
| SCHEMBL1214836 | 0.79 | ELANE (0.64) | ELANEPTGDR2PLA2G2APTGER4MCL1 | |
| SCHEMBL17608485 | 0.77 | ADRA1A (0.43) | ELANEPTGDR2PLA2G2APTGER1NR1H2 | |
| SCHEMBL17608381 | 0.75 | ELANE (0.46) | ELANEPTGDR2PLA2G2APTGER4F2RL3 | |
| SCHEMBL4481117 | 0.75 | PTGER4 (0.54) | PTGER4F2RL3 | |
| SCHEMBL30602811 | 0.72 | PTGDR2 (0.46) | PTGDR2PLA2G2APTGER4NR1H2NR1H3 | |
| SCHEMBL1217296 | 0.71 | CNR1 (0.57) | PTGDR2PLA2G2APTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016041618-A1 | SUBSTITUTED INDAZOLES AND RELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2016-03-24 | — | — | WO | disclosed |