Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GPR6 | P46095 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760885 | 0.92 | RBP4 (0.40) | HSD17B10ALDH1A1GPR6FAAHMAPT | |
| SCHEMBL1761031 | 0.87 | HSD17B10 (0.43) | HSD17B10ALDH1A1GPR6FAAHMEN1 | |
| SCHEMBL1761045 | 0.85 | ACHE (0.39) | ALDH1A1GPR6FAAHKDM4EACHE | |
| SCHEMBL1761072 | 0.84 | ACHE (0.39) | ALDH1A1GPR6FAAHKDM4EMAPT | |
| SCHEMBL1760992 | 0.83 | RBP4 (0.34) | GPR6FAAHMAPTADORA2APDGFRB | |
| SCHEMBL1761008 | 0.82 | KDM4E (0.37) | ALDH1A1GPR6FAAHMEN1KMT2A | |
| SCHEMBL1760930 | 0.82 | FAAH (0.45) | FAAHMEN1KMT2AADORA2AADORA1 | |
| SCHEMBL1760988 | 0.80 | BCHE (0.43) | ALDH1A1GPR6FAAHKDM4EACHE | |
| SCHEMBL1761017 | 0.79 | CYP2D6 (0.44) | ALDH1A1FAAHADORA2AADORA1ADORA2B | |
| SCHEMBL1760878 | 0.79 | FAAH (0.47) | FAAHMAPTADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947692-B2 | Substituted thiazolo[5,4-d]pyrimidine urea derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |