Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 4/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761072 | 0.93 | ACHE (0.39) | ACHEBCHEGPR6MGLLADORA2A | |
| SCHEMBL1761008 | 0.91 | KDM4E (0.37) | ACHEBCHEGPR6ADORA2AFAAH | |
| SCHEMBL1760988 | 0.88 | BCHE (0.43) | ACHEBCHEGPR6ADORA2AHPGDS | |
| SCHEMBL1761013 | 0.85 | HSD17B10 (0.44) | ACHEBCHEGPR6ADORA2AHPGDS | |
| SCHEMBL1760992 | 0.84 | RBP4 (0.34) | GPR6ADORA2AFAAHPDCD1LG2CD274 | |
| SCHEMBL1760885 | 0.83 | RBP4 (0.40) | GPR6FAAHALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL1761006 | 0.83 | FAAH (0.39) | ACHEBCHEADORA2AFAAHPDCD1LG2 | |
| SCHEMBL1761071 | 0.82 | FAAH (0.42) | ACHEBCHEFAAHPDCD1LG2CD274 | |
| SCHEMBL1761054 | 0.81 | FAAH (0.52) | ADORA2AFAAHPDCD1LG2CD274ALDH1A1 | |
| SCHEMBL1761025 | 0.80 | FAAH (0.42) | FAAHPDCD1LG2CD274ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947692-B2 | Substituted thiazolo[5,4-d]pyrimidine urea derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |