Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931938 | 0.89 | PIK3CD (0.37) | ADORA2BADORA2AADORA1SCDKCNH2 | |
| SCHEMBL12592960 | 0.89 | ADORA2A (0.40) | ADORA2BADORA2AADORA1SCD | |
| SCHEMBL1761044 | 0.89 | ADORA2A (0.40) | ADORA2BADORA2AADORA1SCD | |
| SCHEMBL3047619 | 0.85 | RIPK1 (0.37) | ADORA2BADORA2AADORA1SCDKCNH2 | |
| SCHEMBL12592897 | 0.77 | PIK3CD (0.42) | ADORA2BADORA2AADORA1RIPK1RIPK3 | |
| SCHEMBL1760967 | 0.77 | PIK3CD (0.42) | ADORA2BADORA2AADORA1RIPK1RIPK3 | |
| SCHEMBL1761043 | 0.75 | PIK3CD (0.40) | ADORA2BADORA2AADORA1KCNH2P2RX7 | |
| SCHEMBL2932725 | 0.75 | TAS1R3 (0.42) | — | |
| SCHEMBL2931638 | 0.75 | TAS1R3 (0.42) | — | |
| SCHEMBL2931742 | 0.74 | MEN1 (0.38) | ADORA2BADORA2AADORA1SCDRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |