Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3047619 | 0.96 | RIPK1 (0.37) | PIK3CDPIK3CARIPK1RIPK3TRPV1 | |
| SCHEMBL2929522 | 0.89 | ADORA2B (0.37) | RIPK1RIPK3TRPV1P2RX7ADORA2A | |
| SCHEMBL12592897 | 0.89 | PIK3CD (0.42) | PIK3CDPIK3CARIPK1RIPK3TRPV1 | |
| SCHEMBL1760967 | 0.89 | PIK3CD (0.42) | PIK3CDPIK3CARIPK1RIPK3TRPV1 | |
| SCHEMBL1761043 | 0.87 | PIK3CD (0.40) | PIK3CDPIK3CARIPK1RIPK3TRPV1 | |
| SCHEMBL2932725 | 0.86 | TAS1R3 (0.42) | PIK3CDPIK3CA | |
| SCHEMBL2931638 | 0.86 | TAS1R3 (0.42) | PIK3CDPIK3CA | |
| SCHEMBL2931742 | 0.85 | MEN1 (0.38) | RIPK1RIPK3ADORA2AADORA2BADORA1 | |
| SCHEMBL2931691 | 0.85 | TAS1R3 (0.45) | — | |
| SCHEMBL2927299 | 0.83 | PIK3CG (0.36) | PIK3CDPIK3CAADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |