Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612934 | 0.91 | MCHR1 (0.43) | BRAFGPR142ABL1MCHR1 | |
| SCHEMBL12398225 | 0.87 | BRAF (0.54) | BRAFGPR142ABL1BCR | |
| SCHEMBL17612919 | 0.79 | BRAF (0.54) | BRAFGPR142ABL1BCR | |
| SCHEMBL13960002 | 0.78 | ABL1 (0.37) | BRAFGPR142ABL1KCNH2CSF1R | |
| SCHEMBL12398219 | 0.78 | GPR142 (0.54) | BRAFGPR142ABL1BCRMCHR1 | |
| SCHEMBL12398160 | 0.77 | BRAF (0.61) | BRAFGPR142ABL1BCR | |
| SCHEMBL17612910 | 0.74 | BRAF (0.40) | BRAF | |
| SCHEMBL12397171 | 0.74 | GPR142 (0.54) | GPR142ABL1BCR | |
| SCHEMBL17612946 | 0.73 | ABL1 (0.45) | GPR142ABL1CSF1RBCRSRC | |
| SCHEMBL12398217 | 0.72 | BRAF (0.55) | BRAFGPR142ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |