Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 5/20 | 0.31 |
| ▸ | THRB | P10828 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613689 | 0.91 | KDM4E (0.35) | DNM1MAPTCHRM2CHRM4CHRM5 | |
| SCHEMBL17613745 | 0.84 | RAB9A (0.36) | DNM1MAPTCHRM2CHRM4CHRM5 | |
| SCHEMBL17613692 | 0.83 | TSHR (0.36) | MAPTCHRM2CHRM1TSHRKDM4E | |
| SCHEMBL17613731 | 0.81 | THRA (0.31) | CHRM2CHRM1CHRM3KDM4ESMN1; SMN2 | |
| SCHEMBL17613691 | 0.81 | DNM1 (0.30) | DNM1 | |
| SCHEMBL17613741 | 0.76 | RAB9A (0.35) | DNM1MAPTCHRM2CHRM4CHRM5 | |
| SCHEMBL17613702 | 0.76 | TSHR (0.35) | TSHRKDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL17613698 | 0.75 | TSHR (0.43) | MAPTTSHRKDM4ESMN1; SMN2THRB | |
| SCHEMBL17613688 | 0.75 | KDM4E (0.37) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL12022628 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346883-B1 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE | PETERSEN SCOTT G (US) | 2016-03-23 | — | — | EP | disclosed |