Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 12/20 | 0.52 |
| ▸ | PSIP1 | O75475 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168480 | 0.81 | RORC (0.57) | ELANERORC | |
| SCHEMBL16880003 | 0.80 | RORC (0.70) | ELANERORCGAAHSD11B1LMNA | |
| SCHEMBL3497043 | 0.79 | MAPT (0.52) | ALDH1A1 | |
| SCHEMBL18300622 | 0.79 | ALDH1A1 (0.45) | ELANERORCALDH1A1HSD11B1 | |
| SCHEMBL21962301 | 0.79 | CA2 (0.52) | — | |
| SCHEMBL15579071 | 0.79 | ELANE (0.45) | ELANERORCNPC1ALDH1A1RECQL | |
| SCHEMBL15579062 | 0.78 | HRH3 (0.45) | ELANERORCNPC1ALDH1A1RECQL | |
| SCHEMBL9906397 | 0.78 | ALDH1A1 (0.59) | RORCPSIP1GAANPC1ALDH1A1 | |
| SCHEMBL15578026 | 0.76 | PTGS2 (0.46) | ELANE | |
| SCHEMBL15578082 | 0.75 | ELANE (0.44) | ELANENPC1ALDH1A1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015101928-A1 | FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015101928-A1 | FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-09 | — | — | WO | disclosed |
| WO-2012028100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028100-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |